An electrochemical biosensor for clenbuterol detection and pharmacokinetics investigation.

abstract

• Clenbuterol is a member of 2 adrenergic agonists, which is widely used not only as a food additive for livestocks, but also a kind of stimulant for athletes; however, the abuse of clenbuterol may pose a significant negative impact on human health. Since it is highly required to develop fast, sensitive and cost-effective method to determine clenbuterol level in the suspected urine or blood, we herein have fabricated an electrochemical biosensor for the determination of clenbuterol. Measurement of the species with the proposed biosensor can also have the advantages of simplicity, high sensitivity and selectivity. Moreover, the sensor can be directly used for clenbuterol determination in rat urine. We have further studied the pharmacokinetics of clenbuterol by using this proposed electrochemical biosensor, so a new tool to investigate pharmacokinetic is developed in this work.

authors

• Zhu, Xuejun

published proceedings

• Talanta

author list (cited authors)

• Bo, B., Zhu, X., Miao, P., Pei, D., Jiang, B. o., Lou, Y., Shu, Y., & Li, G.

citation count

• 31

complete list of authors

• Bo, Bing||Zhu, Xuejun||Miao, Peng||Pei, Dong||Jiang, Bo||Lou, Yue||Shu, Yongqian||Li, Genxi

publication date

• September 2013

publisher

• Elsevier  Publisher

published in

• Talanta  Journal

keywords

• Adrenergic Beta-Agonists
• Animals
• Biosensing Techniques
• Clenbuterol
• Electrochemical Techniques
• Electrodes
• Female
• Food Contamination
• Gold
• Metal Nanoparticles
• Performance-enhancing Substances
• Platinum
• Rats
• Rats, Sprague-Dawley
• Substance Abuse Detection

PubMed Central ID

• 23708621

Digital Object Identifier (DOI)

• 10.1016/j.talanta.2013.03.056

start page

• 36

end page

• 40

volume

• 113

URL

• http://dx.doi.org/10.1016/j.talanta.2013.03.056