Characterization of AntB, a promiscuous acyltransferase involved in antimycin biosynthesis. Academic Article

abstract

• The in vivo and in vitro characterization of AntB, a dedicated acyltransferase encoded in the antimycin biosynthetic gene cluster, which catalyzes the C-8 acyloxy formation is reported. It is demonstrated that AntB has broad substrate specificity toward both the acyl substrate and the acyl carrier and produces more antimycin analogues with varying C-8 acyloxy moieties.

authors

• Zhu, Xuejun

published proceedings

• Org Lett

author list (cited authors)

• Sandy, M., Zhu, X., Rui, Z., & Zhang, W.

complete list of authors

• Sandy, Moriah||Zhu, Xuejun||Rui, Zhe||Zhang, Wenjun

publication date

• July 2013

publisher

• American Chemical Society (ACS)  Publisher

published in

• Organic Letters  Journal

keywords

• Acyltransferases
• Antimycin A
• Catalysis
• Escherichia Coli
• Magnetic Resonance Spectroscopy
• Multigene Family
• Substrate Specificity

PubMed Central ID

• 23772837

Digital Object Identifier (DOI)

• 10.1021/ol4014365

start page

• 3396

end page

• 3399

volume

• 15

issue

• 13