Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities. Academic Article

abstract

• Covering: up to 2016Antimycin-type depsipeptides are a family of natural products with great structural diversity and outstanding biological activities. These compounds have typically been isolated from actinomycetes and are generated from hybrid nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) assembly lines. This review covers the literature on the four classes of antimycin-type depsipeptides, which differ by macrolactone ring size, and it discusses the discovery, biosynthesis, chemical synthesis, and biological activities of this family of compounds.

authors

• Zhu, Xuejun

published proceedings

• Nat Prod Rep

altmetric score

• 0.75

author list (cited authors)

• Liu, J., Zhu, X., Kim, S. J., & Zhang, W.

citation count

• 57

complete list of authors

• Liu, Joyce||Zhu, Xuejun||Kim, Seong Jong||Zhang, Wenjun

publication date

• October 2016

publisher

• Royal Society of Chemistry (RSC)  Publisher

published in

• Natural Product Reports: a journal of current development in bioorganic chemistry  Journal

keywords

• Actinomyces
• Amino Acid Sequence
• Antimycin A
• Biological Products
• Depsipeptides
• Molecular Structure
• Peptide Synthases

PubMed Central ID

• 27307039

Digital Object Identifier (DOI)

• 10.1039/c6np00004e

start page

• 1146

end page

• 1165

volume

• 33

issue

• 10

URL

• http://dx.doi.org/10.1039/c6np00004e