Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities. Academic Article uri icon


  • Covering: up to 2016Antimycin-type depsipeptides are a family of natural products with great structural diversity and outstanding biological activities. These compounds have typically been isolated from actinomycetes and are generated from hybrid nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) assembly lines. This review covers the literature on the four classes of antimycin-type depsipeptides, which differ by macrolactone ring size, and it discusses the discovery, biosynthesis, chemical synthesis, and biological activities of this family of compounds.

published proceedings

  • Nat Prod Rep

altmetric score

  • 0.75

author list (cited authors)

  • Liu, J., Zhu, X., Kim, S. J., & Zhang, W.

citation count

  • 57

complete list of authors

  • Liu, Joyce||Zhu, Xuejun||Kim, Seong Jong||Zhang, Wenjun

publication date

  • October 2016