Structure-activity-distribution relationship study of anti-cancer antimycin-type depsipeptides. Academic Article uri icon


  • Small-molecule natural products have been an essential source of pharmaceuticals to treat human diseases, but very little is known about their behavior inside dynamic, live human cells. Here, we demonstrate the first structure-activity-distribution relationship (SADR) study of complex natural products, the anti-cancer antimycin-type depsipeptides, using the emerging bioorthogonal Stimulated Raman Scattering (SRS) Microscopy. Our results show that the intracellular enrichment and distribution of these compounds are driven by their potency and specific protein targets, as well as the lipophilic nature of compounds.

published proceedings

  • Chem Commun (Camb)

author list (cited authors)

  • Seidel, J., Miao, Y., Porterfield, W., Cai, W., Zhu, X., Kim, S., ... Zhang, W.

citation count

  • 32

complete list of authors

  • Seidel, Jeremy||Miao, Yupeng||Porterfield, William||Cai, Wenlong||Zhu, Xuejun||Kim, Seong-Jong||Hu, Fanghao||Bhattarai-Kline, Santi||Min, Wei||Zhang, Wenjun

publication date

  • August 2019