Comparative Effectiveness of Carbidopa/Levodopa Enteral Suspension and Deep Brain Stimulation on Pill Burden Reduction in Medicare Fee-for-Service Patients with Advanced Parkinson's Disease. Academic Article uri icon


  • INTRODUCTION: Complex polypharmacy regimens to manage persistent motor fluctuations result in significant pill burden for patients with advanced Parkinson's disease (APD). This study evaluated the effectiveness of carbidopa/levodopa enteral suspension (CLES) and deep brain stimulation (DBS) on reducing pill burden in APD patients. METHODS: We utilized 100% Medicarefee-for-service claims from 2014 to 2018 linked to CLES Patient Support Program (PSP) data. CLES initiators (CLES-I) were propensity matched 1:1 with patients enrolled in PSP who did not initiate treatment (CLES-NI) (N=188) or undergo DBS, and 1:3 with patients who received DBS (N=204, N=612). Average daily pill burden and levodopa equivalent daily dosage (LEDD) were measured at baseline, 0-6months and 7-12months follow-up. RESULTS: CLES-I and CLES-NI had higher pill burden than DBS patients at baseline. However, at 6months post-treatment, CLES-I had significantly fewer pills/day than CLES-NI (4.7 versus 11.4, p<0.05) and DBS (4.8 versus 7.4, p<0.05). A significant reduction in pill burden was observed at 0-6months (46.3%) and 7-12months (68.3%) follow-up for CLES-I (p<0.001) versus increased burden for CLES-NI (+10.5%, p<0.05 and+8.2%, p>0.05) and insignificant reductions for DBS (-3.9% and -6.1%, p>0.05). Mean adjusted pill burden showed 57.3% fewer pills at 0-6months and 74.1% at 7-12months among CLES-I compared with CLES-NI, and 49.6% and 70.1% reduction compared with DBS. CLES-I showed a decrease in LEDD at 7-12months compared with baseline (935 to237mg) and to CLES-NI (237mg versus 1112mg) and DBS patients (236mg versus 594mg). CONCLUSION: CLES led to a significant reduction in pill burden and oral LEDD compared with CLES-NI and DBS patients. Pill burden reduction could be considered a treatment goal for patients with APD challenged by complex polypharmacy regimens that interfere with activities of daily living and quality of life.

published proceedings

  • Neurol Ther

altmetric score

  • 2.25

author list (cited authors)

  • Soileau, M. J., Pagan, F. L., Fasano, A., Rodriguez-Cruz, R., Yan, C. H., Gupta, N. R., ... Siddiqui, M. S.

citation count

  • 0

complete list of authors

  • Soileau, Michael J||Pagan, Fernando L||Fasano, Alfonso||Rodriguez-Cruz, Ramon||Yan, Connie H||Gupta, Niodita R||Teigland, Christie L||Pulungan, Zulkarnain||Schinkel, Jill K||Kandukuri, Prasanna L||Ladhani, Omar A||Siddiqui, Mustafa S

publication date

  • April 2023