Subpopulations of primed T helper cells in rheumatoid arthritis. Academic Article

abstract

• OBJECTIVE: To analyze subsets of primed T helper cells, defined by expression of the CD45RB isoform of the leukocyte common antigen, in the blood and synovial fluid (SF) of patients with rheumatoid arthritis (RA). METHODS: Three-color immunofluorescence was used to study CD45 isoform expression by peripheral blood and SF CD4+ T cells. RESULTS: CD45 isoform expression in the peripheral blood of patients with either RA or reactive arthritis did not differ from that in healthy controls. SF T cells from both RA patients and reactive arthritis patients were almost exclusively primed (CD45RO+) cells. RA SF T cells expressed very low levels of CD45RB; this is the most highly differentiated subset of primed cells. Patients with acute reactive arthritis showed higher levels of CD45RBbright cells in their synovial fluid. CONCLUSION: The highly selected cell population in SF, representing one subset of primed cells, may relate to the apparent functional abnormalities of cells from this site in patients with RA.

authors

• Pilling, Darrell

published proceedings

• Arthritis Rheum

author list (cited authors)

• Matthews, N., Emery, P., Pilling, D., Akbar, A., & Salmon, M.

citation count

• 45

complete list of authors

• Matthews, N||Emery, P||Pilling, D||Akbar, A||Salmon, M

publication date

• May 1993

publisher

• Wiley  Publisher

published in

• ARTHRITIS AND RHEUMATISM  Journal

keywords

• Adult
• Aged
• Arthritis, Reactive
• Arthritis, Rheumatoid
• CD4-Positive T-Lymphocytes
• Female
• Humans
• Leukocyte Common Antigens
• Male
• Middle Aged
• Synovial Fluid

PubMed Central ID

• 8098214

Digital Object Identifier (DOI)

• 10.1002/art.1780360505

start page

• 603

end page

• 607

volume

• 36

issue

• 5

URL

• http://dx.doi.org/10.1002/art.1780360505