Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Academic Article

abstract

• Fibroblasts are important sentinel cells in the immune system and, here, it is proposed that these cells play a critical role in the switch from acute inflammation to adaptive immunity and tissue repair. It is suggested that chronic inflammation occurs because of disordered fibroblast behaviour in which failure to switch off their inflammatory programme leads to the inappropriate survival and retention of leukocytes within inflamed tissue.

authors

• Pilling, Darrell

published proceedings

• Trends Immunol

author list (cited authors)

• Buckley, C. D., Pilling, D., Lord, J. M., Akbar, A. N., Scheel-Toellner, D., & Salmon, M.

citation count

• 485

complete list of authors

• Buckley, CD||Pilling, D||Lord, JM||Akbar, AN||Scheel-Toellner, D||Salmon, M

publication date

• April 2001

publisher

• Elsevier  Publisher

published in

• Trends in Immunology  Journal

keywords

• Acute-phase Reaction
• Animals
• Fibroblasts
• Humans
• Inflammation
• Leukocytes
• Signal Transduction

PubMed Central ID

• 11274925

Digital Object Identifier (DOI)

• 10.1016/s1471-4906(01)01863-4

start page

• 199

end page

• 204

volume

• 22

issue

• 4

URL

• http://dx.doi.org/10.1016/s1471-4906(01)01863-4