Search for highly efficient, stereoselective, and practical synthesis of complex organic compounds of medicinal importance as exemplified by the synthesis of the C21-C37 fragment of amphotericinB. Academic Article uri icon

abstract

  • Highly stereoselective: A highly efficient, stereoselective and practical synthesis of the C21-C37 fragment of amphotericinB was realized in 25% overall yield in eight longest linear steps from commercially available ethyl (S)-3-hydroxybutyrate by using Frter-Seebach alkylation, Brown crotylboration, Negishi coupling, Heck reaction, and Horner-Wadsworth-Emmons (HWE) olefination as key steps (see diagram).

published proceedings

  • Chemistry

altmetric score

  • 9.25

author list (cited authors)

  • Wang, G., Xu, S., Hu, Q., Zeng, F., & Negishi, E.

citation count

  • 4

complete list of authors

  • Wang, Guangwei||Xu, Shiqing||Hu, Qian||Zeng, Fanxing||Negishi, Ei-ichi

publication date

  • January 2013

publisher