One-Step Homologation for the Catalytic Asymmetric Synthesis of Deoxypropionates. Academic Article uri icon

abstract

  • A one-step homologation protocol for the synthesis of natural products containing deoxypropionate motif is described by the combination of Zr-catalyzed asymmetric carboalumination of alkenes (ZACA)-Pd-catalyzed vinylation and ZACA-oxidation reaction. In contrast to most other synthetic strategies used to date that typically require three steps per deoxypropionate unit due to the functional-group interconversions, our one-step homologation strategy promises to provide a general and more efficient synthetic route toward deoxypropionate natural products as exemplified by significant improvements in the syntheses of intermediates and/or final products of mycolipenic acid 1 and its analogue 2, (-)-rasfonin, and syn- and anti-dicarboxylic acids 5 and 6.

published proceedings

  • Chemistry

altmetric score

  • 10.1

author list (cited authors)

  • Xu, S., Li, H., Komiyama, M., Oda, A., & Negishi, E.

citation count

  • 7

complete list of authors

  • Xu, Shiqing||Li, Haijun||Komiyama, Masato||Oda, Akimichi||Negishi, Ei-Ichi

publication date

  • January 2017

publisher