Programmable nanomedicine: synergistic and sequential drug delivery systems. Academic Article

abstract

• Recent developments in nanomedicine for the cancer therapy have enabled programmable delivery of therapeutics by exploiting the stimuli-responsive properties of nanocarriers. These therapeutic systems were designed with the relevant chemical and physical properties that respond to different triggers for enhanced anticancer efficacy, including the reduced development of drug-resistance, lower therapeutic dose, site-specific transport, and spatiotemporally controlled release. This minireview discusses the current advances in programmable nanocarriers for cancer therapy with particular emphasis on synergistic and sequential drug delivery systems.

authors

• Ligler, Frances

published proceedings

• Nanoscale

altmetric score

• 3

author list (cited authors)

• Pacardo, D. B., Ligler, F. S., & Gu, Z.

citation count

• 120

complete list of authors

• Pacardo, Dennis B||Ligler, Frances S||Gu, Zhen

publication date

• February 2015

publisher

• Royal Society of Chemistry (RSC)  Publisher

published in

• Nanoscale  Journal

keywords

• Animals
• Antineoplastic Agents
• Cell Line, Tumor
• DNA
• Delayed-Action Preparations
• Drug Carriers
• Drug Delivery Systems
• Drug Resistance, Neoplasm
• Humans
• Microscopy, Electron, Transmission
• Nanomedicine
• Nanoparticles
• Neoplasms

PubMed Central ID

• 25631684

Digital Object Identifier (DOI)

• 10.1039/c4nr07677j

start page

• 3381

end page

• 3391

volume

• 7

issue

• 8

URL

• http://dx.doi.org/10.1039/c4nr07677j