Immunoregulatory cell subsets in Goodpasture's syndrome: evidence for selective T suppressor-cell depletion during active autoimmune disease. Academic Article uri icon

abstract

  • In a patient with documented untreated Goodpasture's syndrome, serial determination of T-cell subsets using monoclonal antibodies and flow cytometry revealed a persistent but variable deficiency of T-suppressor cells during the period of active disease. As the percentage of OKT8+ cells (suppressor/cytotoxic T cells) returned to normal levels, anti-basement membrane autoantibody production decreased and finally disappeared. Possible pathogenetic implications of immunoregulatory cell imbalance specifically in reference to Goodpasture's syndrome are discussed.

published proceedings

  • J Clin Immunol

author list (cited authors)

  • Ligler, F. S., Westby, G. R., Hertz, B. C., Durning, C. M., Cohen, R., & Bonner, H.

citation count

  • 3

complete list of authors

  • Ligler, FS||Westby, GR||Hertz, BC||Durning, CM||Cohen, R||Bonner, H

publication date

  • October 1983