Immunoregulatory cell subsets in Goodpasture's syndrome: evidence for selective T suppressor-cell depletion during active autoimmune disease.

abstract

• In a patient with documented untreated Goodpasture's syndrome, serial determination of T-cell subsets using monoclonal antibodies and flow cytometry revealed a persistent but variable deficiency of T-suppressor cells during the period of active disease. As the percentage of OKT8+ cells (suppressor/cytotoxic T cells) returned to normal levels, anti-basement membrane autoantibody production decreased and finally disappeared. Possible pathogenetic implications of immunoregulatory cell imbalance specifically in reference to Goodpasture's syndrome are discussed.

authors

• Ligler, Frances

published proceedings

• J Clin Immunol

author list (cited authors)

• Ligler, F. S., Westby, G. R., Hertz, B. C., Durning, C. M., Cohen, R., & Bonner, H.

citation count

• 3

complete list of authors

• Ligler, FS||Westby, GR||Hertz, BC||Durning, CM||Cohen, R||Bonner, H

publication date

• October 1983

publisher

• Springer Nature  Publisher

keywords

• Adult
• Anti-glomerular Basement Membrane Disease
• Antibodies, Monoclonal
• Autoimmune Diseases
• B-Lymphocytes
• Humans
• Kidney Glomerulus
• Leukocyte Count
• Male
• Monocytes
• T-Lymphocytes
• T-Lymphocytes, Regulatory

Digital Object Identifier (DOI)

• 10.1007/BF00915798

start page

• 368

end page

• 374

volume

• 3

issue

• 4

URL

• http://dx.doi.org/10.1007/bf00915798