Bispecific antibodies, nanoparticles and cells: bringing the right cells to get the job done. Academic Article

abstract

• Pre-arming therapeutic cells with bispecific antibodies (BiAbs) before infusion can home the cells to specific tissue antigens in the body. With the development of nanotechnology, we developed a novel strategy, namely magnetic bispecific cell engager (MagBICE), that combines BiAbs with biodegradable iron nanoparticles. Compared to conventional BiAbs, the latter enables magnetic targeting and imaging. This editorial discusses current knowledge of BiAbs and their applications in targeting activated T cells to cancerous tissues or targeting bone marrow-derived stem cells to myocardial infarction. We will also discuss the fabrication of MagBICE and its application in treating rodents with myocardial infarction.

authors

• Ligler, Frances

published proceedings

• Expert Opin Biol Ther

altmetric score

• 6.5

author list (cited authors)

• Tang, J., Shen, D., Zhang, J., Ligler, F. S., & Cheng, K. e.

citation count

• 8

complete list of authors

• Tang, Junnan||Shen, Deliang||Zhang, Jinying||Ligler, Frances S||Cheng, Ke

publication date

• September 2015

publisher

• Taylor & Francis  Publisher

published in

• Expert Opinion on Biological Therapy  Journal

keywords

• Animals
• Antibodies, Bispecific
• Bispecific Antibody
• Cell Therapy
• Cytotoxic T Cells
• Leukocyte Common Antigens
• Lymphocyte Activation
• Magnetic Nanoparticles
• Magnetics
• Mice
• Myocardial Infarction
• Myosin Light Chains
• Nanoparticles
• Regenerative Medicine
• Stem Cell Transplantation
• Stem Cells
• T-Lymphocytes

Digital Object Identifier (DOI)

• 10.1517/14712598.2015.1049944

start page

• 1251

end page

• 1255

volume

• 15

issue

• 9

URL

• http://dx.doi.org/10.1517/14712598.2015.1049944