Inactivation of antigen-responsive clones with antisera specific for IgM or IgD. Academic Article

abstract

• The present study examines the isotype of cell surface immunoglobulins involved in triggering a response to thymus-dependent and thymus-independent antigens. Antibodies to immunoglobulin isotypes were used to block the in vitro interaction of receptor IgD and IgM with antigen. The results indicate that both IgD and IgM are necessary to trigger a response to TNP-SRBC but that only IgM is required for responsiveness to TNP-Brucella. Limiting dilution studies indicate that the inhibition of the immune response by antibody occurs at the level of precursor activation and suggest that there is no effect of antibody on subsequent proliferation of the daughter cells.

authors

• Ligler, Frances

published proceedings

• J Immunol

author list (cited authors)

• Ligler, F. S., Cambier, J. C., Vitetta, E. S., Kettman, J. R., & Uhr, J. W.

citation count

• 7

complete list of authors

• Ligler, FS||Cambier, JC||Vitetta, ES||Kettman, JR||Uhr, JW

publication date

• April 1978

publisher

• The American Association of Immunologists  Publisher

published in

• Journal of Immunology  Journal

keywords

• Animals
• Antibodies, Anti-Idiotypic
• Antibody Specificity
• Antigen-Antibody Reactions
• Goats
• Immunoglobulin D
• Immunoglobulin M
• Immunosuppression Therapy
• Mice
• Rabbits
• Receptors, Antigen, B-Cell
• Spleen
• Thymus Gland

PubMed Central ID

• 305934

Digital Object Identifier (DOI)

• 10.4049/jimmunol.120.4.1139

start page

• 1139

end page

• 1142

volume

• 120

issue

• 4

URL

• http://dx.doi.org/10.4049/jimmunol.120.4.1139