Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma. Academic Article uri icon


  • Regional delivery of chimeric antigen receptor (CAR) T cells in glioblastoma represents a rational therapeutic approach as an alternative to intravenous administration to avoid the blood-brain barrier impediment. Here, we developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release. Using a model of subtotal glioblastoma resection, we demonstrated that the fibrin-based gel delivery of CAR-T cells within the surgical cavity enables superior antitumor activity compared to CAR-T cells directly inoculated into the tumor resection cavity.

published proceedings

  • Sci Adv

altmetric score

  • 82.55

author list (cited authors)

  • Ogunnaike, E. A., Valdivia, A., Yazdimamaghani, M., Leon, E., Nandi, S., Hudson, H., ... Dotti, G.

citation count

  • 20

complete list of authors

  • Ogunnaike, Edikan A||Valdivia, Alain||Yazdimamaghani, Mostafa||Leon, Ernesto||Nandi, Seema||Hudson, Hannah||Du, Hongwei||Khagi, Simon||Gu, Zhen||Savoldo, Barbara||Ligler, Frances S||Hingtgen, Shawn||Dotti, Gianpietro

publication date

  • October 2021