Consuming High-Fat and Low-Fat Ground Beef Depresses High-Density and Low-Density Lipoprotein Cholesterol Concentrations, and Reduces Small, Dense Low-Density Lipoprotein Particle Abundance. Academic Article uri icon


  • We hypothesized that consumption of high-fat (HF) ground beef (24% fat) would not affect plasma concentrations of high-density lipoprotein cholesterol (HDL-C) or low-density lipoprotein (LDL-C), whereas low-fat (LF) ground beef (5% fat) would decrease HDL-C and LDL-C concentrations. In a randomized 2-period crossover, controlled feeding trial, 25 men (mean age and body mass index, 40 years and 31.2) consumed 115-g HF or LF patties, 5/week for 5 weeks with a 4-week washout. The HF treatment increased % energy from fat (p = 0.006) and saturated fat (p = 0.004) and tended (p = 0.060) to depress % energy from carbohydrates. The HF and LF treatments decreased the plasma concentrations of HDL-C (p = 0.001) and LDL-C (p = 0.011). Both ground beef treatments decreased the abundance of HDL3a and increased the abundance of HDL3 (p 0.003); the LF treatment also decreased the abundance of HDL2b and HDL2a (p 0.012). The HF and LF treatments decreased the abundance of LDL3 and LDL4 (p 0.024) and the HF treatment also decreased LDL5 (p = 0.041). Contrary to our hypothesis, the HF treatment decreased plasma HDL-C and LDL-C concentrations despite increased saturated fat intake, and both treatments decreased the abundance of smaller, denser LDL subfractions.

published proceedings

  • Nutrients

altmetric score

  • 0.5

author list (cited authors)

  • Lytle, J. R., Price, T., Crouse, S. F., Smith, D. R., Walzem, R. L., & Smith, S. B.

citation count

  • 1

complete list of authors

  • Lytle, Jason R||Price, Tara||Crouse, Stephen F||Smith, Dana R||Walzem, Rosemary L||Smith, Stephen B

publication date

  • January 2023