Reversible cobalt ion binding to imidazole-modified nanopipettes. Academic Article uri icon


  • In this report, we demonstrate that quartz nanopipettes modified with an imidazole-terminated silane respond to metal ions (Co(2+)) in solution. The response of nanopipettes is evaluated through examination of the ion current rectification ratio. When nanopipettes are cycled between solutions of different pH, adsorbed Co(2+) can be released from the nanopipette surface, to regenerate binding sites of the nanopipette. These results demonstrate that rectification-based sensing strategies for nanopore sensors can benefit from selection of recognition elements with intermediate binding affinities, such that reversible responses can be attained.

published proceedings

  • Anal Chem

altmetric score

  • 6

author list (cited authors)

  • Sa, N., Fu, Y., & Baker, L. A.

citation count

  • 60

complete list of authors

  • Sa, Niya||Fu, Yaqin||Baker, Lane A

publication date

  • December 2010