Reversible cobalt ion binding to imidazole-modified nanopipettes.
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In this report, we demonstrate that quartz nanopipettes modified with an imidazole-terminated silane respond to metal ions (Co(2+)) in solution. The response of nanopipettes is evaluated through examination of the ion current rectification ratio. When nanopipettes are cycled between solutions of different pH, adsorbed Co(2+) can be released from the nanopipette surface, to regenerate binding sites of the nanopipette. These results demonstrate that rectification-based sensing strategies for nanopore sensors can benefit from selection of recognition elements with intermediate binding affinities, such that reversible responses can be attained.
author list (cited authors)
Sa, N., Fu, Y., & Baker, L. A.
complete list of authors
Sa, Niya||Fu, Yaqin||Baker, Lane A