Origin of stereoselectivity in the imidazolidinone-catalyzed reductions of cyclic alpha,beta-unsaturated ketones. Academic Article uri icon


  • The organocatalytic transfer hydrogenation reactions of 3-phenyl-2-cyclopentenone with imidazolidinone catalysts are evaluated using the hybrid density functional (B3LYP/6-31G(d)) theory. The origin of the preference for the (E) iminium transition state is determined, and the stereoselectivity of hydride transfer is investigated.

published proceedings

  • Org Lett

author list (cited authors)

  • Gutierrez, O., Iafe, R. G., & Houk, K. N.

complete list of authors

  • Gutierrez, Osvaldo||Iafe, Robert G||Houk, KN

publication date

  • January 2009