Multiscale Analysis and Nutrient Transport in Carbon Nanotube Reinforced Nanofiber Bioreactor
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Bioreactors play important role in tissue engineering, as they simulate physiological environment required for the development of tissue substitutes. The significant parameters involved in the efficient working of a bioreactor are the transfer of nutrients and removal of wastes. Use of carbon nanotube polymeric scaffolds for tissue engineering applications has gained recent attention, primarily due to the enhanced mechanical properties of carbon nanotubes. In this study, a hierarchical approach to determine the atomistic properties of carbon nanotube based polymers using molecular dynamics and coupling between the scales through complex multi-scale mathematical homogenization models is discussed. A new computational methodology for the analysis of tissue-fluid interaction problem based on a biphasic representation of fluid and tissue domain is also presented. The significance of this work lies in the use of a multi-physical modelling of complex material geometry as well as physical processes that represent different physiological systems, leading to an efficient multiscale-multi-physical computational algorithm. © 2010 American Institute of Physics.
author list (cited authors)
Reddy, J. N., Unnikrishnan, V. U., Unnikrishnan, G. U., Lu, J., Leung, A., Iu, V. P., & Mok, K. M.