A "light" touch on PI3K to interrogate cancer drug resistance.

abstract

• In this issue of Cell Chemical Biology, Ueda etal. (2022) developed PPAP2 as an improved optogenetic tool to photo-induce PI3K signaling hyperactivation in cancer cells. They demonstrated that enhanced translation of tumor necrosis factor alpha-induced protein 8 (TNFAIP8) might explain PI3K hyperactivation-associated resistance toward DNA damaging anti-cancer alkylating agents.

authors

• Zhou, Yubin

published proceedings

• Cell Chem Biol

altmetric score

• 2.1

author list (cited authors)

• Wang, T., Ke, Y., & Zhou, Y.

citation count

• 0

complete list of authors

• Wang, Tianlu||Ke, Yuepeng||Zhou, Yubin

publication date

• November 2022

publisher

• Elsevier  Publisher

published in

• Cell Chemical Biology  Journal

keywords

• Antineoplastic Agents
• Drug Resistance, Neoplasm
• Humans
• Light
• Neoplasms
• Phosphatidylinositol 3-Kinases
• Signal Transduction

PubMed Central ID

• 36400002

Digital Object Identifier (DOI)

• 10.1016/j.chembiol.2022.11.005

start page

• 1573

end page

• 1575

volume

• 29

issue

• 11

URL

• http://dx.doi.org/10.1016/j.chembiol.2022.11.005