A "light" touch on PI3K to interrogate cancer drug resistance. Academic Article uri icon


  • In this issue of Cell Chemical Biology, Ueda etal. (2022) developed PPAP2 as an improved optogenetic tool to photo-induce PI3K signaling hyperactivation in cancer cells. They demonstrated that enhanced translation of tumor necrosis factor alpha-induced protein 8 (TNFAIP8) might explain PI3K hyperactivation-associated resistance toward DNA damaging anti-cancer alkylating agents.

published proceedings

  • Cell Chem Biol

altmetric score

  • 2.1

author list (cited authors)

  • Wang, T., Ke, Y., & Zhou, Y.

citation count

  • 0

complete list of authors

  • Wang, Tianlu||Ke, Yuepeng||Zhou, Yubin

publication date

  • November 2022