MICRO-CONSTITUENT BASED VISCOELASTIC FINITE ELEMENT ANALYSIS OF BIOLOGICAL CELLS Academic Article

abstract

• A viscoelastic analysis of the biological cell considering the microcellular material properties is carried out in this work. Three separate regions of the cell: the actin cortex, cytoplasm and nucleus are considered. The outer cortex and cytoplasm are modeled using standard linear viscoelastic model (SLS) and standard neo-Hookean viscoelastic solid, and a linear elastic material model is considered for the nucleus. The effect of the material properties of cytoplasm and actin cortex on the derivable parameters from three major experimental studies of magnetic twisting cytometry (MTC) and atomic force microscopy (AFM) and micropipette aspiration (MPA) are analyzed using the finite element method. The bead center displacement for the MTC, reaction force for AFM, and aspiration length ratio for the MPA are the major quantities derived from the finite element analysis. A number of parametric studies are also conducted and it is observed that SLS and SnHS models predict nearly identical results for the material constants.

authors

• Reddy, Junuthula

published proceedings

• INTERNATIONAL JOURNAL OF APPLIED MECHANICS

author list (cited authors)

• Cheng, F., Unnikrishnan, G. U., & Reddy, J. N.

citation count

• 4

publication date

• June 2010

publisher

• World Scientific Publishing  Publisher

keywords

• Actin Cortex
• Atomic Force Microscopy
• Cell Mechanics
• Cytoskeleton
• Finite Element Analysis
• Magnetic Twisting Cytometry
• Micropipette Aspiration
• Viscoelasticity

Digital Object Identifier (DOI)

• 10.1142/S1758825110000512

start page

• 229

end page

• 249

volume

• 2

issue

• 2

URL

• http://dx.doi.org/10.1142/s1758825110000512