Enhancing nutritional niche and host defenses by modifying the gut microbiome.

The gut microbiome is essential for processing complex food compounds and synthesizing nutrients that the host cannot digest or produce, respectively. New model systems are needed to study how the metabolic capacity provided by the gut microbiome impacts the nutritional status of the host, and to explore possibilities for altering host metabolic capacity via the microbiome. Here, we colonized the nematode Caenorhabditis elegans gut with cellulolytic bacteria that enabled C.elegans to utilize cellulose, an otherwise indigestible substrate, as a carbon source. Cellulolytic bacteria as a community component in the worm gut can also support additional bacterial species with specialized roles, which we demonstrate by using Lactobacillus plantarum to protect C.elegans against Salmonella enterica infection. This work shows that engineered microbiome communities can be used to endow host organisms with novel functions, such as the ability to utilize alternate nutrient sources or to better fight pathogenic bacteria.

Sun, Q., Vega, N. M., Cervantes, B., Mancuso, C. P., Mao, N., Taylor, M. N., ... Lu, T. K.

Sun, Qing||Vega, Nic M||Cervantes, Bernardo||Mancuso, Christopher P||Mao, Ning||Taylor, Megan N||Collins, James J||Khalil, Ahmad S||Gore, Jeff||Lu, Timothy K

Enhancing nutritional niche and host defenses by modifying the gut microbiome. Academic Article