Cardiovascular abnormalities in dogs with acute pancreatitis. Academic Article uri icon


  • BACKGROUND: The prevalence and clinical importance of cardiac abnormalities in dogs with acute pancreatitis (AP) is unknown. ANIMALS: Twelve dogs with AP and 60 archived serum samples from dogs with suspected AP. METHODS: Two-phase study. PHASE I: Analysis of archived serum samples from dogs with clinical signs of AP and high Spec cPL concentrations. High sensitivity troponin I (TnIH) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations were measured in achieved serum samples. PHASE II: Prospective observational study. Dogs with AP underwent echocardiography and Holter monitoring. Serum cardiac troponin I (cTnI) and plasma NT-proBNP concentrations were measured. Previously described disease severity indices were calculated for each dog. RESULTS: Phase I: 41 of 60 dogs suspected of having AP had abnormally high TnIH concentrations and 13 of 60 had abnormally high serum NT-proBNP concentrations. Higher TnIH concentrations were observed in dogs with Spec cPL concentration>2000g/L as compared to those with concentrations of 1000-2000g/L. PHASE II: 11 of 12 dogs diagnosed with pancreatitis had abnormal cTnI concentrations (median: 0.384ng/mL, range: 0.041-2.966ng/mL, RI: 0.06ng/mL) and 7 of 12 dogs had plasma NT-proBNP concentrations above the reference interval (median: 971pmol/L, range: 250-2215pmol/L, RI: 900pmol/L). Supraventricular and ventricular ectopic beats occurred in 3 dogs. Echocardiographic abnormalities were detected in 5 dogs. Cardiovascular variables were not associated with indices of disease severity. CONCLUSIONS AND CLINICAL IMPORTANCE: Myocardial injury is common in dogs with AP, but clinical consequences appeared to be uncommon in our small cohort. Cardiac biomarkers should be interpreted with caution in dogs with AP.

published proceedings

  • J Vet Intern Med

author list (cited authors)

  • Cridge, H., Langlois, D. K., Steiner, J. M., & Sanders, R. A.

complete list of authors

  • Cridge, Harry||Langlois, Daniel K||Steiner, Jörg M||Sanders, Robert A

publication date

  • November 2022