Thioether binding mediates monofunctional platinum antitumor reagents to trans configuration in DNA interactions. Academic Article

abstract

• Methionine binding converts monofunctional platinum antitumor agents to trans configuration adducts in the reaction with DNA, which suggests the correlation of two classes of platinum complexes in the antitumor mechanism.

authors

• Ma, Guolin

published proceedings

• Chem Commun (Camb)

author list (cited authors)

• Ma, G., Min, Y., Huang, F., Jiang, T., & Liu, Y.

complete list of authors

• Ma, Guolin||Min, Yuanzeng||Huang, Fan||Jiang, Tao||Liu, Yangzhong

publication date

• October 2010

publisher

• Royal Society of Chemistry (RSC)  Publisher

published in

• Chemical Communications  Journal

keywords

• Animals
• Antineoplastic Agents
• Binding Sites
• DNA
• Fishes
• Molecular Structure
• Organoplatinum Compounds
• Stereoisomerism
• Sulfides

PubMed Central ID

• 20730221

Digital Object Identifier (DOI)

• 10.1039/c0cc01408g

start page

• 6938

end page

• 6940

volume

• 46

issue

• 37