Comprehensive review on oral disintegrating films. Academic Article uri icon


  • Fast-dissolving drug-delivery systems were first developed in the late 1970s as an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience difficulties swallowing traditional oral solid dosage forms. In response to this need, a variety of orally disintegrating tablet (ODT) formats were commercialized, which disintegrate within 1 min when placed in the mouth without drinking water or chewing. Oral drug delivery technology has improved from conventional dosage forms to modified release dosage forms to ODT to the recent oral disintegrating films (ODF). Oral disintegrating film or strip that employs a water dissolving polymer which allows the dosage form to quickly hydrate by saliva, adhere to mucosa, and disintegrate within a few seconds, dissolve and releases medication for oromucosal absorption when placed on the tongue or oral cavity. Oral strip technology provides an alternate route for drugs with first pass metabolism. This review give details of materials used in ODF, manufacturing aspects, technologies, evaluation tests and marketed products.

published proceedings

  • Curr Drug Deliv

altmetric score

  • 0.25

author list (cited authors)

  • Nagaraju, T., Gowthami, R., Rajashekar, M., Sandeep, S., Mallesham, M., Sathish, D., & Kumar, Y. S.

citation count

  • 59

complete list of authors

  • Nagaraju, T||Gowthami, R||Rajashekar, M||Sandeep, S||Mallesham, M||Sathish, D||Kumar, Y Shravan

publication date

  • January 2013