Parkinson Disease: Pathophysiology, Genetics, Clinical Manifestations, and Course including Diagnosis and Differential Diagnosis Chapter uri icon


  • Parkinson disease is a neurodegenerative disorder characterized clinically by tremor, rigidity, bradykinesia, and postural instability and pathologically by loss of nigrostriatal neurons and deposition of alpha-synuclein in neuronal cell bodies and neuritis. Non-motor symptoms such as psychiatric disorders, cognitive abnormalities, sleep dysfunction, autonomic dysfunction, and sensory manifestations are also common. This chapter gives a broad overview of this disorder. Sections cover pathophysiology, genetics, clinical manifestations, and disease course. The chapter also briefly discusses how to make the diagnosis, and alternative conditions that should be considered.

author list (cited authors)

  • Soileau, M. J., & Chou, K. L.

complete list of authors

  • Soileau, MJ||Chou, KL

editor list (cited editors)

  • Johnston, M. D., Adams Jr., M. D., & Fatemi, MD, MBA, Ali.

Book Title

  • Neurobiology of Disease, 2 ed

publication date

  • January 2016