Magnetic resonance thermometry at 7T for real-time monitoring and correction of ultrasound induced mild hyperthermia. Academic Article uri icon

abstract

  • While Magnetic Resonance Thermometry (MRT) has been extensively utilized for non-invasive temperature measurement, there is limited data on the use of high field (7T) scanners for this purpose. MR-guided Focused Ultrasound (MRgFUS) is a promising non-invasive method for localized hyperthermia and drug delivery. MRT based on the temperature sensitivity of the proton resonance frequency (PRF) has been implemented in both a tissue phantom and in vivo in a mouse Met-1 tumor model, using partial parallel imaging (PPI) to speed acquisition. An MRgFUS system capable of delivering a controlled 3D acoustic dose during real time MRT with proportional, integral, and derivative (PID) feedback control was developed and validated. Real-time MRT was validated in a tofu phantom with fluoroptic temperature measurements, and acoustic heating simulations were in good agreement with MR temperature maps. In an in vivo Met-1 mouse tumor, the real-time PID feedback control is capable of maintaining the desired temperature with high accuracy. We found that real time MR control of hyperthermia is feasible at high field, and k-space based PPI techniques may be implemented for increasing temporal resolution while maintaining temperature accuracy on the order of 1C.

published proceedings

  • PLoS One

altmetric score

  • 3.5

author list (cited authors)

  • Fite, B. Z., Liu, Y. u., Kruse, D. E., Caskey, C. F., Walton, J. H., Lai, C., ... Ferrara, K. W.

citation count

  • 42

complete list of authors

  • Fite, Brett Z||Liu, Yu||Kruse, Dustin E||Caskey, Charles F||Walton, Jeffrey H||Lai, Chun-Yen||Mahakian, Lisa M||Larrat, Benoit||Dumont, Erik||Ferrara, Katherine W

editor list (cited editors)

  • Najbauer, J.

publication date

  • January 2012