Unimicellar hyperstars as multi-antigen cancer nanovaccines displaying clustered epitopes of immunostimulating peptides. Academic Article

abstract

• Unimicellar hyperstar macromolecular chimeras displaying multiple melanoma peptide antigens were prepared primarily via a combination of click chemistry and esterification reactions starting from a biodegradable hyperbranched polymer template. Solubilization of the hyperstars in aqueous solution afforded a multi-antigen unimicellar cancer nanovaccine of about 20 nm. The nanovaccine showed good biocompatibility and uptake by dendritic cells in vitro. An in vivo evaluation of the nanovaccine therapeutic efficacy against melanoma in mice implanted with B16OVA tumors revealed significantly greater T-cell recruitment and improved survival rates for mice treated with nanovaccine and adjuvant compared to non-treated mice.

authors

• Even, Lisa

published proceedings

• Biomater Sci

altmetric score

• 1

author list (cited authors)

• Kakwere, H., Ingham, E. S., Allen, R., Mahakian, L. M., Tam, S. M., Zhang, H., ... Ferrara, K. W.

citation count

• 7

complete list of authors

• Kakwere, Hamilton||Ingham, Elizabeth S||Allen, Riley||Mahakian, Lisa M||Tam, Sarah M||Zhang, Hua||Silvestrini, Matthew T||Lewis, Jamal S||Ferrara, Katherine W

publication date

• November 2018

publisher

• Royal Society of Chemistry (RSC)  Publisher

published in

• BIOMATERIALS SCIENCE  Journal

keywords

• Adjuvants, Immunologic
• Amino Acid Sequence
• Animals
• Antigens, Neoplasm
• Cancer Vaccines
• Epitopes
• Melanoma
• Mice
• Micelles
• Nanostructures
• Peptides

PubMed Central ID

• 30229768

Digital Object Identifier (DOI)

• 10.1039/c8bm00891d

start page

• 2850

end page

• 2858

volume

• 6

issue

• 11

URL

• http://dx.doi.org/10.1039/c8bm00891d