Single-Chain Atomic Crystals as Extracellular Matrix-Mimicking Material with Exceptional Biocompatibility and Bioactivity. Academic Article uri icon


  • In this study, Mo3Se3- single-chain atomic crystals (SCACs) with atomically small chain diameters of 0.6 nm, large surface areas, and mechanical flexibility were synthesized and investigated as an extracellular matrix (ECM)-mimicking scaffold material for tissue engineering applications. The proliferation of L-929 and MC3T3-E1 cell lines increased up to 268.4 24.4% and 396.2 8.1%, respectively, after 48 h of culturing with Mo3Se3- SCACs. More importantly, this extremely high proliferation was observed when the cells were treated with 200 g mL-1 of Mo3Se3- SCACs, which is above the cytotoxic concentration of most nanomaterials reported earlier. An ECM-mimicking scaffold film prepared by coating Mo3Se3- SCACs on a glass substrate enabled the cells to adhere to the surface in a highly stretched manner at the initial stage of cell adhesion. Most cells cultured on the ECM-mimicking scaffold film remained alive; in contrast, a substantial number of cells cultured on glass substrates without the Mo3Se3- SCAC coating did not survive. This work not only proves the exceptional biocompatible and bioactive characteristics of the Mo3Se3- SCACs but also suggests that, as an ECM-mimicking scaffold material, Mo3Se3- SCACs can overcome several critical limitations of most other nanomaterials.

published proceedings

  • Nano Lett

author list (cited authors)

  • Lee, J. W., Chae, S., Oh, S., Kim, S. H., Choi, K. H., Meeseepong, M., ... Choi, J.

citation count

  • 23

complete list of authors

  • Lee, Jin Woong||Chae, Sudong||Oh, Seoungbae||Kim, Si Hyun||Choi, Kyung Hwan||Meeseepong, Montri||Chang, Jongwha||Kim, Namsoo||Lee, Nae-Eung||Lee, Jung Heon||Choi, Jae-Young

publication date

  • December 2018