Classical and operant conditioning differentially modify the intrinsic properties of an identified neuron. Academic Article uri icon


  • A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify the intrinsic excitability of neuron B51, a critical element for the expression of the feeding response, thus revealing that these two forms of associative learning differ at the cellular level.

published proceedings

  • Nat Neurosci

altmetric score

  • 4

author list (cited authors)

  • Lorenzetti, F. D., Mozzachiodi, R., Baxter, D. A., & Byrne, J. H.

citation count

  • 75

complete list of authors

  • Lorenzetti, Fred D||Mozzachiodi, Riccardo||Baxter, Douglas A||Byrne, John H

publication date

  • January 2006