Quantal mechanism of long-term synaptic potentiation. Academic Article

abstract

• Intracellular recordings were used to demonstrate the occurrence and to analyze the microphysiology of long-term synaptic potentiation (LTP) in the crayfish opener neuromuscular synapse. Brief stimulation of the single excitor motor axon enhanced the amplitudes of subsequent postsynaptic potentials for several hours. Three methods of quantal analysis were used to evaluate the mechanism responsible for LTP. The results of all three methods supported predictions of the hypothesis that LTP results from a presynaptic mechanism that increases the average of neurotransmitter quanta evoked by nerve impulses in the excitor axon.

authors

• Baxter, Douglas

published proceedings

• Proc Natl Acad Sci U S A

author list (cited authors)

• Baxter, D. A., Bittner, G. D., & Brown, T. H.

citation count

• 56

complete list of authors

• Baxter, DA||Bittner, GD||Brown, TH

publication date

• September 1985

publisher

• Proceedings of the National Academy of Sciences  Publisher

published in

• Proceedings of the National Academy of Sciences of the United States of America  Journal

keywords

• Animals
• Astacoidea
• Membrane Potentials
• Neuromuscular Junction
• Neuronal Plasticity
• Synapses
• Time Factors

PubMed Central ID

• 3862111

Digital Object Identifier (DOI)

• 10.1073/pnas.82.17.5978

start page

• 5978

end page

• 5982

volume

• 82

issue

• 17

URL

• http://dx.doi.org/10.1073/pnas.82.17.5978