GEOMETRY, ACTIVITY-DEPENDENT MECHANISMS, MEMBRANE KINETICS AND CHANNEL DENSITY DISTRIBUTION INTERPLAY IN SINGLE NEURON PLASTICITY: A COMPUTATIONAL STUDY Academic Article uri icon

abstract

  • Conduction of action potentials throughout the complex morphology of neurons may be modulated in an activity-dependent manner. Among modulatory mechanisms, afterhyperpolarization (AHP) plays an important role. To investigate how the AHP modulatory capabilities on transmission were dependent on the axonal geometry as well as on membrane properties such as channel kinetics, channel density distribution and membrane noise, multi-compartment computational neural models were built, using the neurosimulator SNNAP. Two kinetic schema for the sodium and potassium channels were compared. The simulations suggest that channel kinetics profoundly influence the AHP-dependent modulation of action potential conduction through points of impedance mismatch in the highly branched neurites of neurons.

published proceedings

  • Biophysical Reviews and Letters

author list (cited authors)

  • CATALDO, E., BRUNELLI, M., AV-RON, E., CAI, Y., & BAXTER, D. A.

citation count

  • 1

complete list of authors

  • CATALDO, ENRICO||BRUNELLI, MARCELLO||AV-RON, EVYATAR||CAI, YIDAO||BAXTER, DOUGLAS A

publication date

  • April 2008