Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior. Academic Article

abstract

• To examine the interaction between molecular, electrical and behavioral circadian rhythms, we combined optogenetic manipulation of suprachiasmatic nucleus (SCN) firing rate with bioluminescence imaging and locomotor activity monitoring. Manipulating firing rate reset circadian rhythms both ex vivo and in vivo, and this resetting required spikes and network communication. This suggests that SCN firing rate is fundamental to circadian pacemaking as both an input to and output of the molecular clockworks.

authors

• Jones, Jeffrey

published proceedings

• Nat Neurosci

altmetric score

• 254.406

author list (cited authors)

• Jones, J. R., Tackenberg, M. C., & McMahon, D. G.

citation count

• 105

complete list of authors

• Jones, Jeff R||Tackenberg, Michael C||McMahon, Douglas G

publication date

• January 2015

publisher

• Springer Nature  Publisher

published in

• Nature Neuroscience  Journal

keywords

• Action Potentials
• Animals
• Channelrhodopsins
• Circadian Rhythm
• In Vitro Techniques
• Luminescent Proteins
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic
• Motor Activity
• Neurons
• Patch-Clamp Techniques
• Period Circadian Proteins
• Photic Stimulation
• Receptors, Dopamine D1
• Sodium Channel Blockers
• Suprachiasmatic Nucleus
• Tetrodotoxin
• Time Factors
• Vasoactive Intestinal Peptide

Digital Object Identifier (DOI)

• 10.1038/nn.3937

start page

• 373

end page

• 375

volume

• 18

issue

• 3

URL

• http://dx.doi.org/10.1038/nn.3937