Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior. Academic Article uri icon


  • To examine the interaction between molecular, electrical and behavioral circadian rhythms, we combined optogenetic manipulation of suprachiasmatic nucleus (SCN) firing rate with bioluminescence imaging and locomotor activity monitoring. Manipulating firing rate reset circadian rhythms both ex vivo and in vivo, and this resetting required spikes and network communication. This suggests that SCN firing rate is fundamental to circadian pacemaking as both an input to and output of the molecular clockworks.

published proceedings

  • Nat Neurosci

altmetric score

  • 254.406

author list (cited authors)

  • Jones, J. R., Tackenberg, M. C., & McMahon, D. G.

citation count

  • 105

complete list of authors

  • Jones, Jeff R||Tackenberg, Michael C||McMahon, Douglas G

publication date

  • January 2015