Host protease activity on bacterial pathogens promotes complement- and antibiotic-directed killing Institutional Repository Document uri icon

abstract

  • ABSTRACTOur understanding of how the host immune system thwarts bacterial evasive mechanisms remains incomplete. Here, we show that host protease neutrophil elastase acts on Acinetobacter baumannii and Pseudomonas aeruginosa to destroy factors that prevent serum-associated, complement-directed killing. The protease activity also enhances bacterial susceptibility to antibiotics in sera. These findings implicate a new paradigm where host protease activity on bacteria acts synergistically with the host complement system and antibiotics to defeat bacterial pathogens.

altmetric score

  • 1

author list (cited authors)

  • Chen, S., Roberts, A., Lu, F., Cannon, C., Qin, Q., & de Figueiredo, P.

citation count

  • 0

complete list of authors

  • Chen, Shaorong||Roberts, Alexandria-Jade||Lu, Felix||Cannon, Carolyn||Qin, Qing-Ming||de Figueiredo, Paul

Book Title

  • bioRxiv

publication date

  • March 2021