Expanding roles for GILT in immunity. Academic Article

abstract

• Gamma-interferon-inducible lysosomal thiol reductase (GILT), a thioredoxin-related oxidoreductase, functions in MHC class II-restricted antigen processing and MHC class I-restricted cross-presentation by reducing disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation. However, recent reports have greatly expanded our understanding of GILT's function. Several studies of GILT and antigen processing have shown that the influence of GILT on the peptide repertoire can alter the character of the immune response and affect central tolerance. Furthermore, a few unexpected roles for GILT have been uncovered: as a host factor for Listeria monocytogenes infection, in the maintenance of cellular glutathione (GSH) levels, and possibly outside the cell, as enzymatically active GILT is secreted by activated macrophages.

authors

• West, Laura

published proceedings

• Curr Opin Immunol

altmetric score

• 0.5

author list (cited authors)

• West, L. C., & Cresswell, P.

citation count

• 61

complete list of authors

• West, Laura Ciaccia||Cresswell, Peter

publication date

• January 2013

publisher

• Elsevier  Publisher

published in

• Current Opinion in Immunology  Journal

keywords

• Animals
• Antigen Presentation
• Autoantigens
• Glutathione
• Humans
• Immune Tolerance
• Immunity, Cellular
• Listeria Monocytogenes
• Listeriosis
• Macrophages
• Oxidation-Reduction
• Oxidoreductases Acting On Sulfur Group Donors

Digital Object Identifier (DOI)

• 10.1016/j.coi.2012.11.006

start page

• 103

end page

• 108

volume

• 25

issue

• 1

URL

• http://dx.doi.org/10.1016/j.coi.2012.11.006