Going against the Tide: Selective Cellular Protein Synthesis during Virally Induced Host Shutoff. Academic Article uri icon


  • Many viral infections cause host shutoff, a state in which host protein synthesis is globally inhibited. Emerging evidence from vaccinia and influenza A virus infections indicates that subsets of cellular proteins are resistant to host shutoff and continue to be synthesized. Remarkably, the proteins of oxidative phosphorylation, the cellular-energy-generating machinery, are selectively synthesized in both cases. Identifying mechanisms that drive selective protein synthesis should facilitate understanding both viral replication and fundamental cell biology.

published proceedings

  • J Virol

altmetric score

  • 3.5

author list (cited authors)

  • Cao, S., Dhungel, P., & Yang, Z.

citation count

  • 16

complete list of authors

  • Cao, Shuai||Dhungel, Pragyesh||Yang, Zhilong

editor list (cited editors)

  • Shisler, J. L.

publication date

  • September 2017