Asparagine: An Achilles Heel of Virus Replication? Academic Article

abstract

• Asparagine biosynthesis and breakdown are tightly regulated in mammalian cells. Recent studies indicate that asparagine supply could be a limiting factor for the replication of some viruses such as vaccinia virus and human cytomegalovirus. In this Viewpoint, we highlight the importance of asparagine metabolism during virus replication and rationalize that asparagine metabolism could be a viable target for broad-spectrum antiviral development. To achieve this goal, more studies into asparagine metabolism during viral infections are demanded. These efforts would benefit beyond viral diseases, as asparagine supply is also a limiting factor in various stages of cancer development.

authors

• Yang, Zhilong

published proceedings

• ACS Infect Dis

altmetric score

• 6

author list (cited authors)

• Pant, A., & Yang, Z.

citation count

• 7

complete list of authors

• Pant, Anil||Yang, Zhilong

publication date

• January 2020

publisher

• American Chemical Society (ACS)  Publisher

published in

• ACS Infectious Diseases  Journal

keywords

• Animals
• Antiviral Agents
• Asparagine
• Cytomegalovirus
• Humans
• Virus Replication
• Viruses

Digital Object Identifier (DOI)

• 10.1021/acsinfecdis.0c00504

start page

• 2301

end page

• 2303

volume

• 6

issue

• 9

URL

• http://dx.doi.org/10.1021/acsinfecdis.0c00504