Preparation of Highly Reactive Lithium Metal Dendrites for the Synthesis of Organolithium Reagents Institutional Repository Document uri icon

abstract

  • A long-standing problem in the area of organolithium chemistry has been the need for a highly reactive Limetal source that mimics Lipowders but has the advantage of being freshly prepared from inexpensive and readily available Lisources. Here we report a simple and convenient activation method using liquid ammonia that furnishes a new Limetal source in the form of crystalline Lidendrites. The Lidendrites were shown to have ca 100 times greater surface area than conventional Lisources created by prototypical mechanical activation methods. Concomitant with the surface area increase, the Lidendrites are 19 times more reactive than Lipowders which are currently the industry standard for the preparation of organolithium compounds. These features were leveraged for the reproducible synthesis of organolithium reagents over a range of common laboratory scales.

altmetric score

  • 14.83

author list (cited authors)

  • Crockett, M., Aguirre, L., Jimenez, L., Hsu, H., & Thomas, A.

citation count

  • 0

complete list of authors

  • Crockett, Michael||Aguirre, Lupita||Jimenez, Leonel||Hsu, Han-Hsiang||Thomas, Andy

Book Title

  • ChemRxiv

publication date

  • July 2022