Dynamics of unfolded nucleosomal fiber. Academic Article uri icon


  • The "rigidity" of chromatin fiber solenoidal structure in different states of condensation was evaluated with the help of gel-electrophoresis. A new property of the unfolded nucleosomal fiber-the capacity to condense with temperature-was demonstrated. These results together with our previously obtained data (W.A. Krajewski et al., Mol. Gen. Genet. 230, pp. 442-448, 1991; W.A. Krajewski et al., Ibid. 231, pp. 17-22, 1991) testify that changes in DNA linking number of transcriptionally active minichromosomes arise in vivo from alteration of nucleosomal solenoid parameters (i.e. from supernucleosomal level of chromatin organization), rather than from core histone modifications only or from increased flexibility of DNA within nucleosomes.

published proceedings

  • J Biomol Struct Dyn

author list (cited authors)

  • Krajewski, W. A., Panin, V. M., & Razin, S. V.

citation count

  • 6

complete list of authors

  • Krajewski, WA||Panin, VM||Razin, SV

publication date

  • January 1993