Acetylation of histones in vitro causes chromatin decompactization. Academic Article uri icon


  • It has been discovered that chemical acetylation of chromatin in vitro by acetyladenylate leads to decrease in the mobility of nucleosomal fiber fragments in agarose gel. Acetylation of HI-depleted chromatin does not produce this effect. Based on these results together with other available data, it is possible to conclude that acetylation causes decompactization of the chromatin fiber. A possible molecular mechanism of in vivo fiber decondensation and interaction of different chromatin compactization levels is discussed.

author list (cited authors)

  • KraevskiÄ­, V. A., Panin, V. M., & Razin, S. V.

citation count

  • 1

publication date

  • January 1994