[Acetylation of histones in vitro causes chromatin decompactization].
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It has been discovered that chemical acetylation of chromatin in vitro by acetyladenylate leads to decrease in the mobility of nucleosomal fiber fragments in agarose gel. Acetylation of HI-depleted chromatin does not produce this effect. Based on these results together with other available data, it is possible to conclude that acetylation causes decompactization of the chromatin fiber. A possible molecular mechanism of in vivo fiber decondensation and interaction of different chromatin compactization levels is discussed.
author list (cited authors)
Kraevski, V. A., Panin, V. M., & Razin, S. V.
complete list of authors
Kraevskiĭ, VA||Panin, VM||Razin, SV