Nanofluidic biosensing for beta-amyloid detection using surface enhanced Raman spectroscopy. Academic Article

abstract

• Trace detection of the conformational transition of beta-amyloid peptide (Abeta) from a predominantly alpha-helical structure to beta-sheet could have a large impact in understanding and diagnosing Alzheimer's disease. We demonstrate how a novel nanofluidic biosensor using a controlled, reproducible surface enhanced Raman spectroscopy active site was developed to observe Abeta in different conformational states during the Abeta self-assembly process as well as to distinguish Abeta from confounder proteins commonly found in cerebral spinal fluid.

authors

• Cote, Gerard
• Kameoka, Jun

published proceedings

• Nano Lett

altmetric score

• 9

author list (cited authors)

• Chou, I., Benford, M., Beier, H. T., Cot, G. L., Wang, M., Jing, N., Kameoka, J., & Good, T. A.

citation count

• 170

complete list of authors

• Chou, I-Hsien||Benford, Melodie||Beier, Hope T||Coté, Gerard L||Wang, Miao||Jing, Nan||Kameoka, Jun||Good, Theresa A

publication date

• June 2008

publisher

• American Chemical Society (ACS)  Publisher

published in

• Nano Letters: a journal dedicated to nanoscience and nanotechnology  Journal

keywords

• Amyloid Beta-Peptides
• Biosensing Techniques
• Equipment Design
• Equipment Failure Analysis
• Microfluidic Analytical Techniques
• Nanotechnology
• Spectrum Analysis, Raman
• Surface Plasmon Resonance

Digital Object Identifier (DOI)

• 10.1021/nl0808132

start page

• 1729

end page

• 1735

volume

• 8

issue

• 6

URL

• http://dx.doi.org/10.1021/nl0808132