Nanofluidic Biosensing for β-Amyloid Detection Using Surface Enhanced Raman Spectroscopy Academic Article uri icon

abstract

  • Trace detection of the conformational transition of beta-amyloid peptide (Abeta) from a predominantly alpha-helical structure to beta-sheet could have a large impact in understanding and diagnosing Alzheimer's disease. We demonstrate how a novel nanofluidic biosensor using a controlled, reproducible surface enhanced Raman spectroscopy active site was developed to observe Abeta in different conformational states during the Abeta self-assembly process as well as to distinguish Abeta from confounder proteins commonly found in cerebral spinal fluid.

author list (cited authors)

  • Chou, I., Benford, M., Beier, H. T., Coté, G. L., Wang, M., Jing, N., Kameoka, J., & Good, T. A.

publication date

  • January 1, 2008 11:11 AM