Nanofluidic biosensing for beta-amyloid detection using surface enhanced Raman spectroscopy. Academic Article uri icon


  • Trace detection of the conformational transition of beta-amyloid peptide (Abeta) from a predominantly alpha-helical structure to beta-sheet could have a large impact in understanding and diagnosing Alzheimer's disease. We demonstrate how a novel nanofluidic biosensor using a controlled, reproducible surface enhanced Raman spectroscopy active site was developed to observe Abeta in different conformational states during the Abeta self-assembly process as well as to distinguish Abeta from confounder proteins commonly found in cerebral spinal fluid.

published proceedings

  • Nano Lett

altmetric score

  • 9

author list (cited authors)

  • Chou, I., Benford, M., Beier, H. T., Cot, G. L., Wang, M., Jing, N., Kameoka, J., & Good, T. A.

citation count

  • 170

complete list of authors

  • Chou, I-Hsien||Benford, Melodie||Beier, Hope T||Coté, Gerard L||Wang, Miao||Jing, Nan||Kameoka, Jun||Good, Theresa A

publication date

  • June 2008