Necrotizing enteritis associated with Clostridium perfringens Type B in chinchillas (Chinchilla lanigera) Academic Article uri icon


  • Four 3-4 month-old chinchillas (Chinchilla lanigera) from a commercial flock of 395 chinchillas, were found dead with evidence of previous diarrhea and prolapsed rectum. A fifth 8 month-old chinchilla died 8 hours after being found recumbent, apathetic, diarrheic and with a prolapsed rectum. Two chinchillas were necropsied and observed gross lesions consisted of extensive hemorrhagic enteritis, mild pulmonary edema and enlarged and yellow liver; this latter finding was particularly prominent in the chinchilla presenting longer clinical course. Histologically there was necrotizing enteritis associated with abundant bacterial rods aggregates in the intestinal surface epithelium and within the lamina propria. In the lungs there were small amounts of pink proteinaceous material (edema) in the interstitium and marked vacuolar hepatocellullar degeneration (lipidosis) in the liver. Anaerobic cultures from the intestinal contents of one of the affected chinchillas yielded Clostridium perfringens. Genotyping of this C. perfringens isolate was achieved by multiplex polymerase chain reaction (mPCR) as C. perfringenstype B due to detection of alpha, beta and epsilon-toxin genes. These findings suggest C. perfringens type B as an important cause of sudden or acute death in chinchillas.

published proceedings


author list (cited authors)

  • Lucena, R. B., Farias, L., Libardoni, F., Vargas, A. C., Giaretta, P. R., & Barros, C.

citation count

  • 2

complete list of authors

  • Lucena, Ricardo B||Farias, Luana||Libardoni, Felipe||Vargas, Agueda C||Giaretta, Paula R||Barros, Claudio SL

publication date

  • December 2011