Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides. Academic Article uri icon


  • Natural products are a major source of biologically active compounds that make promising lead molecules for developing efficacious drug-like molecules. Natural withanolides are found in many flora and fauna, including plants, algae, and corals, that traditionally have shown multiple health benefits and are known for their anti-cancer, anti-inflammatory, anti-bacterial, anti-leishmaniasis, and many other medicinal properties. Structures of these withanolides possess a few reactive sites that can be exploited to design and synthesize more potent and safe analogs. In this review, we discuss the literature evidence related to the medicinal implications, particularly anticancer properties of natural withanolides and their synthetic analogs, and provide perspectives on the translational potential of these promising compounds.

published proceedings

  • Molecules

altmetric score

  • 0.25

author list (cited authors)

  • Singh, A., Raza, A., Amin, S., Damodaran, C., & Sharma, A. K.

citation count

  • 8

complete list of authors

  • Singh, Amandeep||Raza, Asif||Amin, Shantu||Damodaran, Chendil||Sharma, Arun K

publication date

  • January 2022