First Total Syntheses of TetracenomycinsC and X. Academic Article uri icon

abstract

  • The first total syntheses of tetracenomycinsC and X were achieved, featuring 1)preparation of a hexasubstituted naphthonitrile oxide by successive benzyne cycloadditions and an oxidative ring-opening reaction; 2)a novel ortho-quinone mono-acetal as the A-ring unit; 3)construction of three contiguous stereogenic centers by an asymmetric benzoin cyclization, an isoxazole oxidation, and a stereoselective reduction.

published proceedings

  • Angew Chem Int Ed Engl

altmetric score

  • 23.204

author list (cited authors)

  • Sato, S., Sakata, K., Hashimoto, Y., Takikawa, H., & Suzuki, K.

citation count

  • 24

complete list of authors

  • Sato, Shogo||Sakata, Keiichiro||Hashimoto, Yoshimitsu||Takikawa, Hiroshi||Suzuki, Keisuke

publication date

  • October 2017

publisher