Evaluation of a long-acting injectable formulation of omeprazole in healthy dogs.
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BACKGROUND: To evaluate the efficacy of a single intramuscular adminsitration of long-acting omeprazole (LA-OMEP) in increasing gastric pH in dogs. HYPOTHESIS: We hypothesized that LA-OMEP would meet in healthy dogs the clinical goals defined for human patients for treatment of gastroduodenal ulceration. ANIMALS: Nine healthy research dogs. METHODS: Prospective experimental study. Dogs were given a 4mg/kg intramuscular injection of LA-OMEP. Intragastric pH was continuously recorded on treatment days 0 to 7. Daily mean pH and mean percentage time (MPT) intragastric pH was 3 or 4 were determined. RESULTS: The mean onset of action for the LA-OMEP was 98.11min (SD 46.39). The mean number of days the dogs' pH met established goals for MPT pH 3 was 5.5days (range, 3-7) and 5.25days for MPT pH 4 (range, 3-7). Long-acting omeprazole met the human clinical goals pH 3 for 72hours in 8/8 of the dogs and MPT pH 4 for 96hours in 7/8 of dogs. CONCLUSIONS AND CLINICAL IMPORTANCE: The LA-OMEP formulation produced gastric acid suppression in healthy dogs for an average of 5days and up to 7days, after a single intramuscular injection. No major adverse effects were observed.
author list (cited authors)
Odunayo, A., Galyon, G., Price, J., Hecht, S., & Tolbert, M. K.
complete list of authors
Odunayo, Adesola||Galyon, Gina||Price, Joshua||Hecht, Silke||Tolbert, M Katherine