[ 18 F]–NHC–BF 3 adducts as water stable radio-prosthetic groups for PET imaging
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The radiofluorination of N-heterocyclic carbene (NHC) boron trifluoride adducts affords novel [(18)F]-positron emission tomography probes which resist hydrolytic fluoride release. The labelling protocol relies on an (18)F-(19)F isotopic exchange reaction promoted by the Lewis acid SnCl4. Modification of the NHC backbone with a maleimide functionality provides access to a model peptide conjugate which shows no evidence of defluorination when imaged in vivo.
author list (cited authors)
Chansaenpak, K., Wang, M., Wu, Z., Zaman, R., Li, Z., & Gabbaï, F. P.