[ 18 F]–NHC–BF 3 adducts as water stable radio-prosthetic groups for PET imaging Academic Article uri icon

abstract

  • The radiofluorination of N-heterocyclic carbene (NHC) boron trifluoride adducts affords novel [(18)F]-positron emission tomography probes which resist hydrolytic fluoride release. The labelling protocol relies on an (18)F-(19)F isotopic exchange reaction promoted by the Lewis acid SnCl4. Modification of the NHC backbone with a maleimide functionality provides access to a model peptide conjugate which shows no evidence of defluorination when imaged in vivo.

altmetric score

  • 2.35

author list (cited authors)

  • Chansaenpak, K., Wang, M., Wu, Z., Zaman, R., Li, Z., & Gabbaï, F. P.

citation count

  • 26

publication date

  • January 2015