Activation of transposable elements during aging and neuronal decline in Drosophila.

abstract

• We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.

authors

• Li, Wanhe

published proceedings

• Nat Neurosci

altmetric score

• 65.17

author list (cited authors)

• Li, W., Prazak, L., Chatterjee, N., Grninger, S., Krug, L., Theodorou, D., & Dubnau, J.

citation count

• 287

complete list of authors

• Li, Wanhe||Prazak, Lisa||Chatterjee, Nabanita||Grüninger, Servan||Krug, Lisa||Krug, Lisa||Theodorou, Delphine||Theodorou, Delphine||Dubnau, Josh||Dubnau, Josh

publication date

• May 2013

publisher

• Springer Nature  Publisher

published in

• Nature Neuroscience  Journal

keywords

• Aging
• Analysis Of Variance
• Animals
• Animals, Genetically Modified
• Argonaute Proteins
• Avoidance Learning
• Brain
• Conditioning, Classical
• DNA Transposable Elements
• Drosophila
• Drosophila Proteins
• Green Fluorescent Proteins
• Longevity
• Mutation
• Neurons

PubMed Central ID

• 23563579

Digital Object Identifier (DOI)

• 10.1038/nn.3368

start page

• 529

end page

• 531

volume

• 16

issue

• 5

URL

• https://doi.org/10.1038/nn.3368