Activation of transposable elements during aging and neuronal decline in Drosophila. Academic Article uri icon


  • We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.

published proceedings

  • Nat Neurosci

altmetric score

  • 63.44

author list (cited authors)

  • Li, W., Prazak, L., Chatterjee, N., Grninger, S., Krug, L., Theodorou, D., & Dubnau, J.

citation count

  • 236

complete list of authors

  • Li, Wanhe||Prazak, Lisa||Chatterjee, Nabanita||GrĂ¼ninger, Servan||Krug, Lisa||Theodorou, Delphine||Dubnau, Josh

publication date

  • May 2013