Antisense microRNA and uses therefor Patent uri icon

abstract

  • Provided herein are methods to suppress specificity protein (Sp) activity in a cell associated with a cell proliferative disease. The methods are effective to inhibit a microRNA in the cell using an antisense microRNA oligonucleotide which results in an increase in expression of a specificity protein (Sp) suppressor gene thereby inducing Sp degradation, apoptosis or growth arrest by releasing inhibitors of G2/M (Myt-1) or inhibition. Also provided are methods of treating a cancer using the antisense microRNA oligonucleotide. In addition the present invention provides antisense microRNA-27a oligonucleotides useful in the methods described herein.

author list (cited authors)

  • Safe, S. H., Chintharlapalli, S., & Talcott, S. U

complete list of authors

  • Safe, SH||Chintharlapalli, S||Talcott, SU

publication date

  • October 2010