Hemodynamic directed CPR improves short-term survival from asphyxia-associated cardiac arrest. Academic Article uri icon


  • AIM: Adequate coronary perfusion pressure (CPP) during cardiopulmonary resuscitation (CPR) is essential for establishing return of spontaneous circulation. The objective of this study was to compare short-term survival using a hemodynamic directed resuscitation strategy versus an absolute depth-guided approach in a porcine model of asphyxia-associated cardiac arrest. We hypothesized that a hemodynamic directed approach would improve short-term survival compared to depth-guided care. METHODS: After 7 min of asphyxia, followed by induction of ventricular fibrillation, 19 female 3-month old swine (310.4 kg) were randomized to receive one of three resuscitation strategies: (1) hemodynamic directed care (CPP-20): chest compressions (CCs) with depth titrated to a target systolic blood pressure of 100 mmHg and titration of vasopressors to maintain CPP>20 mmHg; (2) depth 33 mm (D33): target CC depth of 33 mm with standard American Heart Association (AHA) epinephrine dosing; or (3) depth 51 mm (D51): target CC depth of 51 mm with standard AHA epinephrine dosing. All animals received manual CPR guided by audiovisual feedback for 10 min before first shock. RESULTS: 45-Min survival was higher in the CPP-20 group (6/6) compared to D33 (1/7) or D51 (1/6) groups; p=0.002. Coronary perfusion pressures were higher in the CPP-20 group compared to D33 (p=0.011) and D51 (p=0.04), and in survivors compared to non-survivors (p<0.01). Total number of vasopressor doses administered and defibrillation attempts were not different. CONCLUSIONS: Hemodynamic directed care targeting CPPs>20 mmHg improves short-term survival in an intensive care unit porcine model of asphyxia-associated cardiac arrest.

published proceedings

  • Resuscitation

altmetric score

  • 13.008

author list (cited authors)

  • Sutton, R. M., Friess, S. H., Bhalala, U., Maltese, M. R., Naim, M. Y., Bratinov, G., ... Berg, R. A.

citation count

  • 89

complete list of authors

  • Sutton, Robert M||Friess, Stuart H||Bhalala, Utpal||Maltese, Matthew R||Naim, Maryam Y||Bratinov, George||Niles, Dana||Nadkarni, Vinay M||Becker, Lance B||Berg, Robert A

publication date

  • May 2013