Effect of Dietary L-Threonine and Toxin Binder on Performance, Blood Parameters, and Immune Response of Broilers Exposed to Aflatoxin B1. Academic Article uri icon


  • To evaluate the effect of L-Threonine (L-Thr) and Mycofix Plus (MP) on aflatoxicosis, an experiment with a 3-way ANOVA model was carried out with 8 replicates and 640 birds. Treatments included two levels of L-Thr (100% and 125% of the requirements, Cobb 500, Cobb-Vantress), Aflatoxin B1 (AFB1) (0, 500 ppb), and MP (0, 1 g/kg). As the main effects showed, AFB1 decreased breast meat yield and carcass percentage (p < 0.001), serum urea, antibody titer against infectious bronchitis virus (IBV), and bone density (p < 0.05), while it increased the plasma concentrations of glucose and alkaline phosphatase (ALP) (p < 0.05). Mycofix Plus improved the grower feed intake (FI), tibia fresh weight, and body weight (BW) to bone weight (p < 0.05). L-Threonine increased the grower FI, breast meat yield, serum aspartate transaminase (AST), and glutathione peroxidase (GPX) (p < 0.05). There were positive interactions with breast meat yield, cholesterol, lactate dehydrogenase (LDH), and IBV titer. Of the treatments used, the combination of L-Thr and MP without AFB1 improved breast meat and carcass percentage. L-Threonine and MP significantly improved IBV titer in birds challenged with AFB1 (p < 0.001). In conclusion, L-Thr and MP were beneficial to improve immunity.

published proceedings

  • Toxins (Basel)

altmetric score

  • 1.6

author list (cited authors)

  • Mesgar, A., Aghdam Shahryar, H., Bailey, C. A., Ebrahimnezhad, Y., & Mohan, A.

citation count

  • 5

complete list of authors

  • Mesgar, Aydin||Aghdam Shahryar, Habib||Bailey, Christopher Anthony||Ebrahimnezhad, Yahya||Mohan, Anand

publication date

  • January 2022


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