The Functional Roles of Immune Cells in Primary Liver Cancer.

abstract

• Primary liver cancer includes hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Incidence of liver cancer has been increasing in recent years, and the 5-year survival is <20%. HCC and CCA are often accompanied with a dense stroma coupled with infiltrated immune cells, which is referred to as the tumor microenvironment. Populations of specific immune cells, such as high density of CD163+ macrophages and low density of CD8+ T cells, are associated with prognosis and survival rates in both HCC and CCA. Immune cells in the tumor microenvironment can be a therapeutic target for liver cancer treatments. Previous studies have introduced immunotherapy using immune checkpoint inhibitors, pulsed dendritic cells, or transduced T cells, to enhance cytotoxicity of immune cells and inhibit tumor growth. This review summarizes current understanding of the roles of immune cells in primary liver cancer covering HCC and CCA.

authors

• Chakraborty, Sanjukta

published proceedings

• Am J Pathol

altmetric score

• 7.55

author list (cited authors)

• Pham, L., Kyritsi, K., Zhou, T., Ceci, L., Baiocchi, L., Kennedy, L., ... Sato, K.

citation count

• 2

complete list of authors

• Pham, Linh||Kyritsi, Konstantina||Zhou, Tianhao||Ceci, Ludovica||Baiocchi, Leonardo||Kennedy, Lindsey||Chakraborty, Sanjukta||Glaser, Shannon||Francis, Heather||Alpini, Gianfranco||Sato, Keisaku

publication date

• June 2022

publisher

• Elsevier  Publisher

published in

• American Journal of Pathology  Journal

keywords

• Bile Duct Neoplasms
• Bile Ducts, Intrahepatic
• CD8-Positive T-Lymphocytes
• Carcinoma, Hepatocellular
• Cholangiocarcinoma
• Humans
• Liver Neoplasms
• Tumor Microenvironment

PubMed Central ID

• 35337836

Digital Object Identifier (DOI)

• 10.1016/j.ajpath.2022.02.004

start page

• 826

end page

• 836

volume

• 192

issue

• 6

URL

• http://dx.doi.org/10.1016/j.ajpath.2022.02.004

user-defined tag

• 3 Good Health and Well-Being